Principal Investigator: Prof Carlos Penedo



A correlative, ultra-stable, optical tweezers-confocal microscope for high-resolution molecular and cellular mechanobiology
Funding body: BBSRC ALERT22 (Grant number: BB/X019047/1). Start date: July 2023, duration: 1 year. Amount awarded: £642k. Lead PI: Prof Carlos Penedo.
Exploring interactions of polar fluoroaliphatic motifs with biomolecules
Funding body: EPSRC (Grant number: EP/X038904/1). Start date: January 2024, duration: 3 years. Amount awarded: £752k. PI: Prof David O'Hagan, Co-PIs: Prof Carlos Penedo and Dr Georg Haehner.
Untying the knot: Remodelling of G4 structures by the NER machinery- implications in human DNA repair and regulatory pathways.
Funding body: University of St Andrews and University of Bonn, Global Doctoral Scholarship. Start date: September 2023. Amount awarded: £110k. PIs: Prof Carlos Penedo (St Andrews) and Prof Katrin Paeschke (Bonn).
Janus cyclohexanes: A new class of nucleic acid affinity probes.
Funding body: University of St Andrews, St Leonards World-leading PhD Scholarship. Start date: September 2023. Amount awarded: £110k. PIs: Prof David O'Hagan and Prof Carlos Penedo.
Live-cell, deep-tissue, low-light, 3D-STED confocal microscopy: a super-resolution imaging platform specifically designed for plant science.
Funding body: BBSRC ALERT21 (Grant number:BB/W019752/1). Start date: July 2022. Amount awarded: £810k. Lead PI: Alison Roberts (James Hutton Institute), Co-PIs: Carlos Penedo and others.
Visualizing SARS-Cov-2 fusion to host cells using single-molecule microscopy
Funding body: University of St Andrews, St Leonard's College, Word-leading St Andrews Doctoral Scholarhip. Start date: September 2021. Amount awarded: £110k. Lead PI: Dr. Carlos Penedo, Co-PIs: Dr. Juan Varela and Prof Terry Smith.
Enabling shaped pulsed capability for superior biological structure determination using EPR spectroscopy
Funding body: BBSRC (Grant number: BB/T017740/1), 19ALERT mid-range equipment initiative. Lead PI: Janet Lovett, Co-PIs: Carlos Penedo and others, Start: June 2020, End: June 2021, Duration 1 year, Amount awarded: £352k.
Ultra-fast, ultra-small and ultradilute: an integrated understanding of conjugated polymers in solution across temporal and spatial scales
Funding body: EPSRC (Grant number: EP/T013729/1) Joint application between St Andrews and Glasgow University. Lead Institution: Univ. St Andrews. Lead PI: Carlos Penedo, Co-PIs: Ifor Samuel (St Andrews) and Peter Skabara (Glasgow), Start: March 2020, End: December 2023, Amount awarded: £1.1M (£0.7M St Andrews and £0.4M Glasgow)

Nucleotide excision repair-lighting up a dark pathway
Funding body: BBSRC (BB/R015570/1) PI: Malcolm F White, Co-PI: Carlos Penedo, Start: August 2018, End: September 2021, Duration 3 years, Amount awarded: £604k

Single-molecule studies of light-emitting polymers: observing and manipulating polymer conformation in solution
Funding body: EPSRC (EP/N009886/1), PI: Carlos Penedo, Co-PI: Ifor D. W. Samuel, Joint application with Strathclyde (Co-PI: Prof. P. Skabara). Lead institution: Univ. St Andrews. Start: Feb 2016, End: July 2019. Amount awarded: £580k

Probing the molecular network associated to FOXP transcriptional regulation
Funding Body: Royal Society (Newton Advanced Fellowship,NAF\R2\180787): PIs: Carlos Penedo & Sylvia Fanucchi. Start:Jan 2019, End Dec 2021. Amount awarded: £103k

     
TWIN-FRET: A novel perspective for next generation distance measurements in biological systems
Funding body: Royal Society (NF170334) Newton Fellowship awarded to Dr Sankar Jana. PI: Carlos Penedo. Start: Feb 2018. End: January 2020. Amount awarded: £66k

Cryogen-free arbitrary waveform EPR for structural biology and biophysics.
Funding body: BBSRC (BB/R013780/1), PI: Bela Bode, Co-PI: Carlos Penedo and others. Amount awarded: £150k

     
Single-molecule studies of DNA repair complexes
Funding body: Welcome Trust ISSF, PI: Carlos Penedo, Co-PI: Malcolm F White. Duration: 3.5 years. Start: 2017, End: 2020. Amount awarded: £35k

     
Enabling precision distance measurements in long RNAs
Funding body: BBSRC (BB/R021848/1). PI: Edward Anderson (Univ. Oxford), Co-PIs: Janet Lovett & Carlos Penedo (Univ. St Andrews). Duration 14 months. Amount awarded: £187k

Development of an assay for amyloid growth using photonic-based technologies
Funding body: RS MacDonlad Trust. PI: Carlos Penedo. Amount awarded: £33k

     
Multi-functional machines acting on DNA: XPB and XPD helicases
Funding Body: Welcome Trust (091825/Z/10/Z). PI: Malcolm F. White, Co-PIs: Jim Naismith and Carlos Penedo, Start: September 2010, End: October 2014. Amount awarded: £900k

     
Single-molecule studies of glycine-sensing riboswitches
Funding body: Royal Society PI: Carlos Penedo. Start: March 2007, End: April 2008. Amount awarded: £15k

     
Organization and function of structure-specific endonucleases
Funding body: BBSRC (BB/E014674/1). PI: Carlos Penedo, Co-PI: Malcolm F White. Start: July 2007, End: June 2010. Amount awarded: £415k