BL5421 Chromatin and Genome Stability

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Module description

This module will introduce you to the fundamental concepts of chromatin structure and function and how this affects genome stability. DNA repair and telomere maintenance are perhaps the most significant factors affecting genome stability and these processes are central to the understanding of cancer cell biology. Indeed, most existing anti-cancer agents induce DNA damage and current efforts to target chromatin factors therapeutically are showing promise. You will have the opportunity to independently research and present seminars on the applied biology of chromatin and DNA repair within model organisms such as budding yeast, Caenorhabditis elegans and Drosophila melanogaster. The seminars and student presentations will be supplemented with guest lectures from scientists at the cutting edge of chromatin research and students will also have the opportunity to engage in research debates on topics at the forefront of modern cancer biology. Importantly, you will be expected to design and defend a research proposal that addresses an unsolved question of your choice within the field of genome stability.