Prof James Ainge
Head of the School of Psychology and Neuroscience
Professor
Research areas
The focus of the lab is to try and understand the neural mechanisms that support our ability to remember the things that have happened to us – episodic memory. Most of our work takes a systems neuroscience approach to examine how networks within the hippocampus and entorhinal cortex process memory information. We use in vivo electrophysiology to examine firing patterns of individual neurons as lab rats carry out memory tasks. We also use molecular and genetic tools to manipulate the network and understand the cellular mechanisms underlying episodic memory.
Complimenting the neuroscientific approach, other lines of research in the lab examine the cognitive mechanisms underlying episodic memory in both human adults and children. Ultimately, we aim to apply this work by using our knowledge of mammalian memory networks to help test therapeutic strategies for disorders of memory such as Alzheimer’s disease.
PhD supervision
- Benjamin Thompson
Selected publications
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Open access
Context in memory is reconstructed, not encoded
Easton, A., Horner, A. J., James, S. J., Kendal, J., Sutton, J. & Ainge, J. A., Dec 2024, In: Neuroscience and Biobehavioral Reviews. 167, 105934.Research output: Contribution to journal › Review article › peer-review
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Open access
Increased flexibility of CA3 memory representations following environmental enrichment
Ventura, S., Duncan, S. & Ainge, J., 6 May 2024, In: Current Biology. 34, 9, p. 2011-2019Research output: Contribution to journal › Article › peer-review
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Open access
Measuring episodic memory and mental time travel: Crossing the species gap
Collaro, E., Barton, R. A., Ainge, J. A. & Easton, A., 16 Sept 2024, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 379, 1913, 20230406.Research output: Contribution to journal › Review article › peer-review
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Open access
Building partnerships: a case study of physical activity researchers and practitioners collaborating to build evidence to inform the delivery of a workplace step count challenge
Niven, A., Ainge, J. A., Allison, M., Gorely, T., Kelly, P., Ozakinci, G., Ryde, G. C., Tomaz, S. A., Warne, S., Whiteford, V. & Greenwood, C., 4 Jan 2023, In: Frontiers in Sports and Active living. 4, 8 p., 1067127.Research output: Contribution to journal › Article › peer-review
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Open access
Editorial: neurobiology of spontaneous object exploration in recognition memory
Chao, O., Barbosa, F. F., Inostroza, M., Ainge, J. A. & Li, J.-S., 3 May 2023, In: Frontiers in Behavioral Neuroscience. 17, 3 p., 1184935.Research output: Contribution to journal › Editorial › peer-review
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Open access
Leptin-based hexamers facilitate memory and prevent amyloid-driven AMPA receptor internalisation and neuronal degeneration
Doherty, G. H., Holiday, A., Malekizadeh, Y., Manolescu, C., Duncan, S., Flewitt, I., Hamilton, K., MacLeod, B., Ainge, J. & Harvey, J., 1 Jun 2023, In: Journal of Neurochemistry. 165, 6, p. 809-826 18 p.Research output: Contribution to journal › Article › peer-review
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Open access
Lateral entorhinal cortex lesions impair odor-context associative memory in male rats
Persson, B. M., Ambrozova, V., Duncan, S., Wood, E., O'Connor, A. R. & Ainge, J., 22 Mar 2022, In: Journal of Neuroscience Research. 100, 4, p. 1030-1046 17 p.Research output: Contribution to journal › Article › peer-review
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Open access
Editorial: Spring Hippocampal Research Conference and Beyond
Ainge, J. A., Chisari, M., Cohen, A., Mennerick, S. J., Topolnik, L. & Meier, J. C., 12 Oct 2021, In: Frontiers in Molecular Neuroscience. 14, 773308.Research output: Contribution to journal › Editorial › peer-review
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Open access
Object and object-memory representations across the proximodistal axis of CA1
Vandrey, B., Duncan, S. & Ainge, J. A., 20 Jul 2021, In: Hippocampus. 31, 8, p. 881-896 16 p.Research output: Contribution to journal › Article › peer-review
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Open access
Perirhinal cortex and the recognition of relative familiarity
Ameen-Ali, K. E., Sivakumaran, M., Eacott, M. J., O'Connor, A. R., Ainge, J. A. & Easton, A., Jul 2021, In: Neurobiology of Learning and Memory. 182, 107439.Research output: Contribution to journal › Article › peer-review