Biography
Dr. Danial obtained his D.Phil. in Physical and Theoretical Chemistry from the University of Oxford as a Weidenfeld-Louis Dreyfus scholar under the supervision of Professor Mark I Wallace (now Professor of Chemistry at King's College London). Subsequently, he joined the group of Professor Ana Garcia-Saez (now Director at the Max Planck Institute for Biophysics) at the Max Planck Institute for Intelligent Systems and the Interfaculty Institute of Biochemistry at the University of Tuebingen as a Max Planck Society-funded postdoctoral research fellow. He later transitioned to the University of Cambridge as an EISAI and UK Dementia Research Institute (UK DRI) funded postdoctoral research associate in the group of Professor Sir David Klenerman FRS (Royal Society Research Professor) at the Yusuf Hamied Department of Chemistry and the UK DRI at the University of Cambridge. He also held positions as a College Research Associate (CRA) at King's College, Cambridge, and a Bye Fellow at Homerton College, Cambridge.
Research areas
Biology and disease are heterogenous. It is hard to visualise, quantify, and qualify this heterogeneity at the structural and ultra-structural levels, within single proteins and protein assemblies, and in human and cellular samples. We are a research lab developing new instrumentation, assays, and software to push single molecule and super resolution microscopy towards structural imaging one-molecule-at-a-time. Together with collaborators, we aim to democratise these technologies and use them to study the molecular architecture of cellular complexes, from the Kinetochore to pore-forming proteins, and human diseases, from neurodegenerative to immune disorders in living human samples. Group website: daniallab.com
Selected publications
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Open access
Co-aggregation with apolipoprotein E modulates the function of amyloid-β in Alzheimer's disease
Xia, Z., Prescott, E. E., Urbanek, A., Wareing, H. E., King, M. C., Olerinyova, A., Dakin, H., Leah, T., Barnes, K. A., Matuszyk, M. M., Dimou, E., Hidari, E., Zhang, Y. P., Lam, J. Y. L., Danial, J. S. H., Strickland, M. R., Jiang, H., Thornton, P., Crowther, D. C. & Ohtonen, S. & 11 others, , 1 Jun 2024, In: Nature Communications. 15, 1, 18 p., 4695.Research output: Contribution to journal › Article › peer-review
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Open access
Gasdermin D cysteine residues synergistically control its palmitoylation-mediated membrane targeting and assembly
Margheritis, E., Kappelhoff, S., Danial, J., Gehle, N., Kohl, W., Kurre, R., González Montoro, A. & Cosentino, K., 1 Oct 2024, In: EMBO Journal. 43, 19, p. 4274-4297 24 p.Research output: Contribution to journal › Article › peer-review
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Open access
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s disease
Rajani, R. M., Ellingford, R., Hellmuth, M., Harris, S. S., Taso, O. S., Graykowski, D., Lam, F. K. W., Arber, C., Fertan, E., Danial, J. S. H., Swire, M., Lloyd, M., Giovannucci, T. A., Bourdenx, M., Klenerman, D., Vassar, R., Wray, S., Sala Frigerio, C., Busche, M. A. & Simons, M. (Editor), 23 Jul 2024, (E-pub ahead of print) In: PLoS Biology. 22, 7, 30 p., e3002727.Research output: Contribution to journal › Article › peer-review