Dr Janet Lovett
Senior Lecturer
Research areas
Measuring nanometre distances for structural biology using EPR spectroscopy.
I use Electron Paramagnetic Resonance (EPR) spectroscopy to measure nanometre distances in proteins and nucleic acids. This provides detail on their structure and dynamics. The methodology is applied to a range of proteins including those for protein excretion in the cell. I am also interested in developing the methods for tagging proteins and nucleic acids to make them suitable for this kind of investigation, as well as advancing the EPR experiments themselves.
The biological preparation and EPR facilities at St Andrews are outstanding with, among others, pulsed and CW X-band, high power Q-band and the home-built high power W-band (HiPER).
PhD supervision
- Elena Mocanu
Selected publications
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Open access
Robustness and sensitivity of Gd(III)-Gd(III) double electron electron resonance (DEER) measurements: comparative study of high-frequency EPR spectrometer designs and spin label variants
Mocanu, E. M., Ben-Ishay, Y., Topping, L., Fisher, S. R., Hunter, R. I., Su, X.-C., Butler, S., Smith, G. M., Goldfarb, D. & Lovett, J. E., 3 Jan 2025, (E-pub ahead of print) In: Applied Magnetic Resonance. Early View, 21 p.Research output: Contribution to journal › Article › peer-review
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Open access
Spirocyclic pyrrolidinyl nitroxides with exo-methylene substituents
Sowiński, M. P., Warnke, A.-L., Lund, B. A., Skagseth, S., Cordes, D. B., Lovett, J. E. & Haugland, M. M., 13 Dec 2024, In: ChemPlusChem. 89, 12, 7 p., e202400387.Research output: Contribution to journal › Article › peer-review
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Open access
Conformational tuning improves the stability of spirocyclic nitroxides with long paramagnetic relaxation times
Sowiński, M. P., Gahlawat, S., Lund, B. A., Warnke, A.-L., Hopmann, K. H., Lovett, J. E. & Haugland, M. M., 5 Jun 2023, In: Communications Chemistry. 6, 1, 8 p., 111.Research output: Contribution to journal › Article › peer-review
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The Photochemical Mediated Ring Contraction of 4H-1,2,6-Thiadiazines To Afford 1,2,5-Thiadiazol-3(2H)-one 1-Oxides
Broumidis, E., Thomson, CG., Gallagher, B., Sotorríos, L., Mckendrick, KG., Macgregor, SA., Paterson, MJ., Lovett, JE., Lloyd, GO., Rosair, GM., Kalogirou, AS., Koutentis, PA. & Vilela, F., 11 Sept 2023, In: Organic Letters. 25, 37, p. 6907-6912 6 p.Research output: Contribution to journal › Article › peer-review
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Open access
Design of the elusive proteinaceous oxygen donor copper site suggests a promising future for copper for MRI contrast agents
Shah, A., Taylor, M. J., Molinaro, G., Anbu, S., Verdu, M., Jennings, L., Mikulska, I., Diaz-Moreno, S., El Mkami, H., Smith, G. M., Britton, M. M., Lovett, J. E. & Peacock, A. F. A., 4 Jul 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 27, e2219036120.Research output: Contribution to journal › Article › peer-review
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Open access
The photochemical mediated ring contraction of 4H-1,2,6-thiadiazines to afford 1,2,5-thiadiazol-3(2H)-one 1-oxides
Broumidis, E., Thomson, C. G., Gallagher, B., Sotorríos, L., McKendrick, K. G., Macgregor, S. A., Paterson, M. J., Lovett, J. E., Lloyd, G. O., Rosair, G. M., Kalogirou, A. S., Koutentis, P. A. & Vilela, F., 22 Sept 2023, In: Organic Letters. 25, 37, p. 6907-6912 6 p.Research output: Contribution to journal › Article › peer-review
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Open access
Triggered functional dynamics of AsLOV2 by time-resolved electron paramagnetic resonance at high magnetic fields
Maity, S., Price, B. D., Wilson, C. B., Mukherjee, A., Starck, M., Parker, D., Wilson, M. Z., Lovett, J. E., Han, S. & Sherwin, M. S., 20 Mar 2023, In: Angewandte Chemie International Edition. 62, 13, 9 p., e202212832.Research output: Contribution to journal › Article › peer-review
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Open access
Combined pulsed electron double resonance EPR and molecular dynamics investigations of calmodulin suggest effects of crowding agents on protein structures
Stewart, A., Shanmugam, M., Kutta, R., Scrutton, N., Lovett, J. E. & Hay, S., 6 Sept 2022, In: Biochemistry. 61, 17, p. 1735–1742 8 p.Research output: Contribution to journal › Article › peer-review
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Open access
DEER data analysis software: a comparative guide
Russell, H., Cura, R. & Lovett, J. E., 1 Jun 2022, In: Frontiers in Molecular Biosciences. 9, 17 p., 915167.Research output: Contribution to journal › Article › peer-review
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Open access
Neural networks in pulsed dipolar spectroscopy: a practical guide
Keeley, J., Choudhury, T., Galazzo, L., Bordignon, E., Feintuch, A., Goldfarb, D., Russell, H., Taylor, M. J., Lovett, J. E., Eggeling, A., Fabregas Ibanez, L., Keller, K., Yulikov, M., Jeschke, G. & Kuprov, I., May 2022, In: Journal of Magnetic Resonance. 338, 14 p., 107186.Research output: Contribution to journal › Article › peer-review
