Dr Wilber Sabiiti
Principal Research Fellow
Biography
I am a biomedical scientist with interest in translational research, working on the interface of applied biological science and healthcare provision. My work takes a holistic approach from primary discovery and optimisation in the laboratory to addressing barriers of translating biomedical research innovations into policy and practice. Achieving this kind of work requires interdisciplinary approach and expertise, which I have achieved by bringing together international minds in various research consortia primary between UK and Africa but also continental Europe, Asia and North America. In recent years my group has focused on the development and optimisation of rapid tests for quantification of bacteria responsible for tuberculosis (TB) disease and exacerbation of Chronic Obstructive Pulmonary Disease (COPD). This work has resulted in the tuberculosis Molecular Bacterial Load Assay (TB-MBLA), the first ever fully quantitative test for quantifying patient TB bacterial load and measuring the change of this load as patient responds to treatment. Working with interdisciplinary team of researchers from UK, USA and East Africa, we tackled the biolgical and socioeconomic drivers of antimicrobial resistance (AMR), and the impact of COVID-19 on antibiotics use and risk of AMR rise. Owing to the rise in epidemics of viral origin, my research portifolio has expanded to include molecular diagnostics for viral infections, vaccine development and access in low resource settings. Besides research I teach Introductory Epidemiology, Respiratory infections, and tuberculosis pathology, diagnosis and treatment to Bachelor of Medicine- and Interdisciplinary approaches to solving global health challenges to Master of International development- students. I contribute to advancement of research through guest/academic editorship (Frontiers Cellualar & Infection Microbiology, Frontiers Antibiotics, East African Science, and PLoS Global Public Health) and over 20 peer reviews per year for several academic journals. In addition I am member of fulculties of experts for different funding streams including UKRI Applied Global Health, South Africa Medical Research Council, Africa Research Excellence Fund, Commonwealth Scholarship Commission Academic Adviser panel, NIHR College of Experts for the Global Effort on COVID-19, and Newton Fund Biomedical Sciences. I am Co-Chair Immunology & Diagnostics Working Group of the Coalition for Equitable Research in Low Resource Settings (CERCLE), Co-Chief Investigator Africa Vaccine Research Network (AFRIVAXn), Co-ordinator St ANdrews-Africa Health Research newtork (StAAHR) and a TDR/WHO Antimicrobial resitance Knowledge management consultant.
PhD supervision
- Ritah Nakiboneka
- Winters Muttamba
Selected publications
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Accuracy of the tuberculosis molecular bacterial load assay to diagnose and monitor response to anti-tuberculosis therapy: a longitudinal comparative study with standard-of-care smear microscopy, Xpert MTB/RIF Ultra, and culture in Uganda
Musisi, E., Wamutu, S., Ssengooba, W., Kasiinga, S., Sessolo, A., Sanyu, I., Kaswabuli, S., Zawedde, J., Byanyima, P., Kia, P., Muwambi, W., Toskin, D. T., Kigozi, E., Walbaum, N., Dombay, E., Legrady, M. B., Ssemambo, K. D-M., Joloba, M., Kuchaka, D., Worodria, W., & 3 others , 5 Mar 2024, (E-pub ahead of print) In: The Lancet Microbe.Research output: Contribution to journal › Article › peer-review
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Open access
A high-performance thin-layer chromatography densitometric method for the separation of isomeric ceftriaxone in powder for injection formulation
Mwamwitwa, K. W., Nyamweru, B., Iwodyah, M. A., Sambu, G., Nyondo, G. G., Yondu, E., Fimbo, A. M., Manyanga, V., Sabiiti, W., Shewiyo, D. H., Shearer, M. C., Smith, A. D. & Kaale, E. A., 1 Nov 2024, In: Scientific Reports. 14, 9 p., 26308.Research output: Contribution to journal › Article › peer-review
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Open access
Accuracy of the tuberculosis molecular bacterial load assay to diagnose and monitor response to anti-tuberculosis therapy: a longitudinal comparative study with standard-of-care smear microscopy, Xpert MTB/RIF Ultra, and culture in Uganda
Musisi, E., Wamutu, S., Ssengooba, W., Kasiinga, S., Sessolo, A., Sanyu, I., Kaswabuli, S., Zawedde, J., Byanyima, P., Kia, P., Muwambi, W., Toskin, D. T., Kigozi, E., Walbaum, N., Dombay, E., Legrady, M. B., Ssemambo, K.D.-M., Joloba, M., Kuchaka, D. & Worodria, W. & 3 others, , Apr 2024, In: The Lancet Microbe. 5, 4, p. e345-e354Research output: Contribution to journal › Article › peer-review
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Open access
Adverse drug reactions resulting from the use of chiral medicines amoxicillin, amoxicillin-clavulanic acid, and ceftriaxone: a mixed prospective-retrospective cohort study
Mwamwitwa, K. W., Bukundi, E. M., Maganda, B. A., Munishi, C., Fimbo, A. M., Buma, D., Muro, E. P., Sabiiti, W., Shewiyo, D. H., Shearer, M. C., Smith, A. D. & Kaale, E. A., 15 Sept 2024, (E-pub ahead of print) In: INQUIRY: The Journal of Health Care Organization, Provision, and Financing. 61, 18 p.Research output: Contribution to journal › Article › peer-review
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Open access
Developing biomarkers assays to accelerate tuberculosis drug development: defining target product profiles
Gillespie, S. H., DiNardo, A. R., Georghiou, S. B., Sabiiti, W., Kohli, M., Panzner, U., Kontsevaya, I., Hittel, N., Stuyver, L. J., Tan, J. B., van Crevel, R., Lange, C., Nguyen, T. T. T., Heyckendorf, J., Ruhwald, M. & Heinrich, N., 9 May 2024, (E-pub ahead of print) In: The Lancet Microbe. In Press, 11 p.Research output: Contribution to journal › Review article › peer-review
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Open access
Etiology and antimicrobial susceptibility patterns of bacteria causing pneumonia among adult patients with signs and symptoms of lower respiratory tract infections during the COVID-19 pandemic in Mwanza, Tanzania: a cross-sectional study
Rukyaa, J., Mushi, M. F., Silago, V., Damiano, P., Keenan, K., Sabiiti, W., Holden, M. T. G., Seni, J. & Mshana, S. E., 5 Sept 2024, In: Pneumonia. 16, 10 p., 16.Research output: Contribution to journal › Article › peer-review
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Open access
Evidencing the intersection of environmental, socioeconomic, behavioural and demographic drivers of antibacterial resistance in East Africa
Keenan, K., Papathomas, M., Mshana, S. E., Asiimwe, B., Kiiru, J., Lynch, A. G., Kesby, M., Neema, S., Mwanga, J. R., Mushi, M. F., Green, D. L., Jing, W., Olamijuwon, E., Zhang, Q., Sippy, R., Fredricks, K. J., Gillespie, S. H., Sabiti, W., Bazira, J. & Sloan, D. J. & 7 others, , 15 Feb 2024, Rochester, NY: SSRN, 26 p.Research output: Working paper › Preprint
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Improved Diagnosis and Treatment Monitoring of Tuberculosis Using Stool and the Tuberculosis Bacterial Load Assay (TB-MBLA)
Musisi, E., Mtafya, B., Wambi, W. S., Zawedde, J., Sessolo, A., Ssengooba, W., Walbaum, N., Ntinginya, N. E., Gillespie, S. H. & Sabiiti, W., 2024, In: Methods in Molecular Biology. 2833, p. 153-160 8 p.Research output: Contribution to journal › Article
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Intersecting social and environmental determinants of multidrug-resistant urinary tract infections in East Africa beyond antibiotic use
HATUA Consortium, 31 Oct 2024, In: Nature Communications. 15, 1, p. 9418Research output: Contribution to journal › Article › peer-review
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Increasing access and application of bioethics in Africa: a Tanzanian case study
Mwangi, R., Sabiiti, W., Mtuy, T., Temba, B., Nyindo, M., Mcharo, R., Ntinginya, N. E., Mssusa, A., Kafuye, M. & Mmbaga, B., 30 May 2024, An African research ethics reader: from the ground up. Iyioke, I., Uwanduoma Maduabuchi, J.-M., Onyeka, T. & O'Rourke, M. (eds.). Leiden: Brill, p. 220-253 34 p. (Africana philosophy; vol. 1).Research output: Chapter in Book/Report/Conference proceeding › Chapter