Dr Mustafa Elshani

Research Fellow

Researcher profile

Email

me56@st-andrews.ac.uk

 

Research areas

I'm a research fellow in Professor David Harrison's group, and my work primarily revolves around transcriptomic profiling of cancer. We utilise long-read sequencing techniques on various samples, including in-vitro cell lines, patient-derived tumouroids, and biopsies. Our particular focus lies in understanding drug-induced changes to RNA regulation within cancer cells. Employing various approaches including spatial transcriptomics and multiplex protein analysis, we aim to understand the RNA regulatory impact on protein expression and cellular phenotype.

PhD supervision

• Minyeoung Kweon
• Hazem Abdullah
• Etang Collins Etang

Selected publications

• Open access

  Transcription factor NFE2L1 decreases in glomerulonephropathies after podocyte damage

  Elshani, M., Um, I. H., Leung, S., Reynolds, P. A., Chapman, A., Kudsy, M. & Harrison, D. J., 29 Aug 2023, In: Cells. 12, 17, 2165.

  Research output: Contribution to journal › Article › peer-review

• Open access

  NUC-7738 regulates β-catenin signalling resulting in reduced proliferation and self-renewal of AML cells

  Shahid, M. A., Um, I. H., Elshani, M., Zhang, Y. & Harrison, D. J., 15 Dec 2022, In: PLoS ONE. 17, 12, 13 p., e0278209.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Spatial analysis of NQO1 in non-small cell lung cancer shows its expression is independent of NRF1 and NRF2 in the tumor microenvironment

  Kaghazchi, B., Um, I. H., Elshani, M., Read, O. J. & Harrison, D. J., 8 Nov 2022, In: Biomolecules. 12, 11, 16 p., 1652.

  Research output: Contribution to journal › Article › peer-review

• Open access

  The novel nucleoside analogue ProTide NUC-7738 overcomes cancer resistance mechanisms in vitro and in a first-in-human Phase 1 clinical trial

  Schwenzer, H., De Zan, E., Elshani, M., van Stiphout, R., Kudsy, M., Morris, J., Ferrari, V., Um, I. H., Chettle, J., Kazmi, F., Campo, L., Easton, A., Nijman, S., Serpi, M., Symeonides, S., Plummer, R., Harrison, D. J., Bond, G. & Blagden, S. P., 8 Sept 2021, (E-pub ahead of print) In: Clinical Cancer Research. Early, 15 p.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Tissue-specific immunopathology in fatal COVID-19

  ICECAP consortium, Dorward, D. A., Russell, C. D., Um, I. H., Elshani, M., Armstrong, S. D., Penrice-Randal, R., Millar, T., Lerpiniere, C. E. B., Tagliavini, G., Hartley, C. S., Randle, N. P., Gachanja, N. N., Potey, P. M. D., Dong, X., Anderson, A. M., Campbell, V. L., Duguid, A. J., Al Qsous, W., BouHaidar, R., & 9 others Baillie, J. K., Dhaliwal, K., Wallace, W. A., Bellamy, C. O. C., Prost, S., Smith, C., Hiscox, J. A., Harrison, D. J. & Lucas, C. D., 15 Jan 2021, In: American Journal of Respiratory and Critical Care Medicine. 203, 2, p. 192-201

  Research output: Contribution to journal › Article › peer-review

• Open access

  YAP translocation precedes cytoskeletal rearrangement in podocyte stress response: a podometric investigation of diabetic nephropathy

  Haley, K., Elshani, M., Um, I. H., Bell, C., Caie, P. D., Harrison, D. J. & Reynolds, P. A., 15 Jul 2021, In: Frontiers in Physiology. 12, 10 p., 625762.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Podocyte injury elicits loss and recovery of cellular forces

  Haley, K., Kronenberg, N. M., Liehm, P., Elshani, M., Bell, C., Harrison, D. J., Gather, M. C. & Reynolds, P. A., 27 Jun 2018, In: Science Advances. 4, 6, 9 p., eaap8030.

  Research output: Contribution to journal › Article › peer-review

 

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