Dr Derek Sloan

Reader/Consultant in Infectious Diseases

Researcher profile

Phone

+44 (0)1334 46 3577

Email

djs26@st-andrews.ac.uk

 

Research areas

I have worked in both high and low income countries, accruing extensive experience in the management of infectious diseases, particularly tuberculosis (TB). I have successfully obtained research grant funding and completed a Wellcome Trust fellowship in Liverpool and Malawi, culminating in the award of a PhD from the University of Liverpool.

My research is targeted towards clinical therapeutics questions of global public health significance. Presentation and publication of my work has resulted in Young Investigator Awards and prizes at major international conferences. I have ongoing projects on the clinical pharmacology of anti-TB drugs, PK-PD modeling of responses to anti-microbial therapy and programmatic interventions to reduce mortality from infectious diseases in low resource settings.

I also have an interest in the acute management of infectious disease outbreaks, and supported the UKMed/NHS response to the Ebola Virus Disease epidemic in West Africa in 2015.

Year	My role	Funding source
2016-2019	Co-investigator	EDCTP HIV/TB diagnostics; a one-stop shop for the same day diagnosis and management of TB and HIV
2015-2018	Supervisor/ Advisor	Commonwealth PhD Scholarship/ Epistem Optimizing the Diagnosis and Management of Tuberculosis (TB) and Diabetes Mellitus (DM) among HIV Patients in a high TB and HIV burden setting (student: Rotimi Owolabi)
2015-2018	Primary Supervisor	Wellcome Trust Clinical PhD Fellowship awarded to Dr Andrew McCallum
2015-2017	Principal Investigator	British Society for Antimicrobial Chemotherapy Effect of MIC distribution on clinical PK-PD modelling to predict treatment outcome in pulmonary TB patients from Blantyre, Malawi
2015-2017	Principal Investigator	Wellcome Trust Institutional Strategic Support Fund Grant to LSTM Drug resistance in TB: Microbiological & pharmacological variability influencing outcomes
2015-2017	Co-investigator	Wellcome Trust Institutional Strategic Support Fund Grant to LSTM Rational development of an optimal treatment regimen for isoniazid mono-resistant TB
2010-2012	Co-investigator & collaborator	Wellcome Trust Masters Training Fellowship awarded to Mr David Mzinza
2008-2012	Principal Investigator	Wellcome Trust Clinical PhD Fellowship
2008	Principal Investigator	LSTM Equipment Grant (Awarded to set up a mycobacterial liquid culture facility in BSL3 laboratory)

PhD supervision

• Katherine Hill
• Hellen Onyango
• Ritah Nakiboneka
• Eva Agnes Laker Odongpiny
• Muge Cevik

Selected publications

• Open access

  Bedaquiline-pretomanid-moxifloxacin-pyrazinamide for drug-sensitive and drug-resistant pulmonary tuberculosis treatment: a phase 2c, open-label, multicentre, partially randomised controlled trial

  Cevik, M., Thompson, L. C., Upton, C., Rolla, V. C., Malahleha, M., Mmbaga, B., Ngubane, N., Abu Bakar, Z., Rassool, M., Variava, E., Dawson, R., Staples, S., Lalloo, U., Louw, C., Conradie, F., Eristavi, M., Samoilova, A., Skornyakov, S. N., Ntinginya, N. E. & Haraka, F. & 28 others, Praygod, G., Mayanja-Kizza, H., Caoili, J., Balanag, V., Dalcolmo, M. P., McHugh, T., Hunt, R., Solanki, P., Bateson, A., Crook, A. M., Fabiane, S., Timm, J., Sun, E., Spigelman, M., Sloan, D. J., Gillespie, S. H., Bruinenberg, P., Beumont, M., Nedelman, J., Li, M., Zuma-Gwala, N., Rajaram, S., Choo, L., Wills, G., Betteridge, M., Leandra, L., Olugbosi, M. & Borisov, S., 1 Sept 2024, In: The Lancet Infectious Diseases. 24, 9, p. 1003-1014 12 p.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Bedaquiline: what might the future hold?

  Shaw, E. S., Stoker, N. G., Potter, J. L., Claassen, H., Leslie, A., Tweed, C. D., Chiang, C.-Y., Conradie, F., Esmail, H., Lange, C., Pinto, L., Rucsineanu, O., Sloan, D. J., Theron, G., Tisile, P., Voo, T. C., Warren, R. M., Lebina, L. & Lipman, M., 27 Jul 2024, (E-pub ahead of print) In: The Lancet Microbe. In Press, 8 p., 100909.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Evidencing the intersection of environmental, socioeconomic, behavioural and demographic drivers of antibacterial resistance in East Africa

  Keenan, K., Papathomas, M., Mshana, S. E., Asiimwe, B., Kiiru, J., Lynch, A. G., Kesby, M., Neema, S., Mwanga, J. R., Mushi, M. F., Green, D. L., Jing, W., Olamijuwon, E., Zhang, Q., Sippy, R., Fredricks, K. J., Gillespie, S. H., Sabiti, W., Bazira, J. & Sloan, D. J. & 7 others, Mmbaga, B. T., Kibiki, G., Stelling, J., Smith, V. A., Sandeman, A., Holden, M. T. G. & HATUA Consortium, 15 Feb 2024, Rochester, NY: SSRN, 26 p.

  Research output: Working paper › Preprint

• Open access

  Intersecting social and environmental determinants of multidrug-resistant urinary tract infections in East Africa beyond antibiotic use

  Keenan, K. L., Papathomas, M., Mshana, S., Asiimwe, B., Kiiru, J., Lynch, A., Kesby, M., Neema, S., Mwanga, J. R., Mushi, M. F., Jing, W., Green, D. L., Olamijuwon, E. O., Zhang, Q., Sippy, R., Fredricks, K. J., Gillespie, S. H., Sabiiti, W., Bazira, J. & Sloan, D. J. & 8 others, HATUA Consortium, Kibiki, G., Mmbaga, B. T., Aanensen, D., Stelling, J., Smith, V. A., Sandeman, A. & Holden, M., 31 Oct 2024, In: Nature Communications. 15, 11 p., 9418.

  Research output: Contribution to journal › Article › peer-review

• Intersecting social and environmental determinants of multidrug-resistant urinary tract infections in East Africa beyond antibiotic use

  HATUA Consortium, 31 Oct 2024, In: Nature Communications. 15, 1, p. 9418

  Research output: Contribution to journal › Article › peer-review

• Predictable excess hepatotoxicity in the SimpliciTB trial - Authors' reply

  Cevik, M., Beumont, M., Sun, E., Sloan, D. J. & Gillespie, S. H., 28 Oct 2024, (E-pub ahead of print) In: Lancet Infectious Diseases.

  Research output: Contribution to journal › Article

• Open access

  Treatment seeking behaviours, antibiotic use and relationships to multi-drug resistance: A study of urinary tract infection patients in Kenya, Tanzania and Uganda

  HATUA Consortium, Feb 2024, In: PLOS Global Public Health. 4, 2, e0002709.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Predominance of multidrug-resistant bacteria causing urinary tract infections among symptomatic patients in East Africa: a call for action

  Maldonado-Barragán, A., Mshana, S. E., Keenan, K., Ke, X., Gillespie, S. H., Stelling, J., Maina, J., Bazira, J., Muhwezi, I., Mushi, M. F., Green, D. L., Kesby, M., Lynch, A. G., Sabiiti, W., Sloan, D. J., Sandeman, A., Kiiru, J., Asiimwe, B. & Holden, M. T. G., Feb 2024, In: JAC-Antimicrobial Resistance. 6, 1, 11 p., dlae019.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Specific human gene expression in response to infection is an effective marker for diagnosis of latent and active tuberculosis

  Nakiboneka, R., Walbaum, N., Musisi, E., Nevels, M., Nyirenda, T., Nliwasa, M., Msefula, C. L., Sloan, D. & Sabiiti, W., 6 Nov 2024, In: Scientific Reports. 14, 15 p., 26884.

  Research output: Contribution to journal › Article › peer-review

• Localization and phenotyping of tuberculosis bacteria using a combination of deep learning and SVMs

  Zachariou, M., Arandjelovic, O., Dombay, E., Sabiiti, W., Mtafya, B., Ntinginya, NE. & Sloan, DJ., Dec 2023, In: Computers in Biology and Medicine. 167, 13 p., 107573.

  Research output: Contribution to journal › Article › peer-review

 

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