Research areas
I am a Research Fellow in the Harrison Lab working on on various research projects surrounding the role of the lipidome in the tumor microenvironment using the latest spatial and imaging technologies with a focus on mass spectrometry.
PhD supervision
- Hazem Abdullah
- Greice Zickuhr
Selected publications
-
Open access
DESI-MSI-guided exploration of metabolic-phenotypic relationships reveals a correlation between PI 38:3 and proliferating cells in clear cell renal cell carcinoma via single-section co-registration of multimodal imaging
Zickuhr, G. M., Um, I. H., Laird, A., Harrison, D. J. & Dickson, A., Jul 2024, In: Analytical and Bioanalytical Chemistry. 416, 18, p. 4015–4028 14 p.Research output: Contribution to journal › Article › peer-review
-
Open access
Defining the mode of action of cisplatin combined with NUC-1031, a phosphoramidate modification of gemcitabine
Patel, D., Dickson, A., Zickuhr, G. M., Um, I. H., Read, O. J., Melo Czekster, C., Mullen, P., Harrison, D. J. & Bre, J. L., 1 Dec 2024, In: Translational Oncology. 50, 11 p., 102114.Research output: Contribution to journal › Article › peer-review
-
Open access
Snapshots of the reaction coordinate of a thermophilic 2'-deoxyribonucleoside/ribonucleoside transferase
Tang, P., Harding, C. J., Dickson, A., da Silva, R. G., Harrison, D. J. & Melo Czekster, C., 1 Mar 2024, In: ACS Catalysis. 14, 5, p. 3090-3102 13 p.Research output: Contribution to journal › Article › peer-review
-
Open access
Catalytic cycle of the bifunctional enzyme phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-AMP cyclohydrolase
Fisher, G., Pecaver, E., Read, B., Leese, S., Laing, E., Dickson, A., Melo Czekster, C. & da Silva, R. G., 2 Jun 2023, In: ACS Catalysis. 13, 11, p. 7669-7679 11 p.Research output: Contribution to journal › Article › peer-review
-
Open access
HSD3B1 is an oxysterol 3β-hydroxysteroid dehydrogenase in human placenta
Dickson, A., Yutuc, E., Thornton, C. A., Dunford, J. E., Oppermann, U., Wang, Y. & Griffiths, W. J., 3 May 2023, In: Open Biology. 13, 5, 19 p., 220313.Research output: Contribution to journal › Article › peer-review
-
Open access
Human 2'-deoxynucleoside 5'-phosphate N-hydrolase 1: mechanism of 2'-deoxyuridine 5'-monophosphate hydrolysis
Devi, S., Carberry, A. E., Zickuhr, G. M., Dickson, A., Harrison, D. J. & da Silva, R. G., 5 Sept 2023, In: Biochemistry. 62, 17, p. 2658-2668 11 p.Research output: Contribution to journal › Article › peer-review
-
Open access
The novel anti-cancer fluoropyrimidine NUC-3373 is a potent inhibitor of thymidylate synthase and an effective DNA-damaging agent
Bré, J. L., Dickson, A., Read, O. J., Zhang, Y., McKissock, F. G., Mullen, P., Tang, P., Zickuhr, G. M., Melo Czekster, C. & Harrison, D. J., 31 Mar 2023, In: Cancer Chemotherapy and Pharmacology. 12 p.Research output: Contribution to journal › Article › peer-review
-
Open access
Identification of unusual oxysterols biosynthesised in human pregnancy by charge-tagging and liquid chromatography - mass spectrometry
Dickson, A. L., Yutuc, E., Thornton, C. A., Wang, Y. & Griffiths, W. J., 10 Nov 2022, In: Frontiers in Endocrinology. 13, 19 p., 1031013.Research output: Contribution to journal › Article › peer-review
-
Open access
Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates
Abdel-Khalik, J., Hearn, T., Dickson, A. L., Crick, P. J., Yutuc, E., Austin-Muttitt, K., Bigger, B. W., Morris, A. A., Shackleton, C. H., Clayton, P. T., Iida, T., Sircar, R., Rohatgi, R., Marschall, H.-U., Sjövall, J., Björkhem, I., Mullins, J. G. L., Griffiths, W. J. & Wang, Y., Feb 2021, In: The Journal of Steroid Biochemistry and Molecular Biology. 206, 15 p., 105794.Research output: Contribution to journal › Article › peer-review
-
Open access
Deep mining of oxysterols and cholestenoic acids in human plasma and cerebrospinal fluid: quantification using isotope dilution mass spectrometry
Yutuc, E., Dickson, A. L., Pacciarini, M., Griffiths, L., Baker, P. R. S., Connell, L., Öhman, A., Forsgren, L., Trupp, M., Vilarinho, S., Khalil, Y., Clayton, P. T., Sari, S., Dalgic, B., Höflinger, P., Schöls, L., Griffiths, W. J. & Wang, Y., 15 Apr 2021, In: Analytica Chimica Acta. 1154, 16 p., 338259.Research output: Contribution to journal › Article › peer-review