Research areas
My research is interdisciplinary and sits at the interface between the basic sciences and medicine. Research in my laboratory is focused upon how metal ions are handled in the body and the roles they play in regulating medically/physiologically relevant processes. Collectively, my work provides detailed and reliable data relating to the transport and speciation of metal ions (particularly zinc and calcium) in the circulation and new insights into their cellular functions and role in disease states. Currently my team are examining ways in which defective metal handling contributes to pathogenesis of cardiovascular diseases, including vascular eye disease and dementia.
PhD supervision
- Timothy Redpath
- Claudia Harper
- Keira Hughes
- Quenton Hurst
- Hasnain Ahmed
- Boyang Lin
- Mark Kelly
- Jordan Marsh
Selected publications
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Properties of the major Zn2+-binding site of human alpha-fetoprotein, a potential foetal plasma zinc carrier
Lu, J., Hierons, S. J., Arya, S., Fritzen, R., Polepalli, S., Khazaipoul, S., Stewart, A. J. & Blindauer, C. A., 4 Feb 2025, In: Chemical Communications. 61, 10, p. 2099-2102 4 p.Research output: Contribution to journal › Article › peer-review
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Open access
Quantitative proteomics identifies plasma protein alterations that associate with metabolic and thrombotic profile changes after bariatric surgery
Ahmed, H., Fernandes, M. F., Abbas, K., Synowsky, S. A., Shirran, S. L., Ajjan, R. A. & Stewart, A. J., 25 Feb 2025, (E-pub ahead of print) In: Diabetes, Obesity and Metabolism. Early View, 11 p.Research output: Contribution to journal › Article › peer-review
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The importance of understanding why the Co2+-binding ability of albumin is reduced in ischemia
Stewart, A. J. & Blindauer, C. A., Apr 2025, In: International Journal of Gynecology & Obstetrics. 169, 1, p. 441-442 2 p.Research output: Contribution to journal › Letter › peer-review
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Open access
Changes in fibrin clot properties in patients after Roux en-Y gastric bypass surgery
Abbas, K., Hierons, S. J., Pechlivani, N., Phoenix, F., Alexander, R., King, R., Ajjan, R. A. & Stewart, A. J., Feb 2024, In: Research and Practice in Thrombosis and Haemostasis. 8, 2, 8 p., e102361.Research output: Contribution to journal › Article › peer-review
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Open access
EPR spectroscopic characterisation of native CuII-binding sites in human serum albumin
Ackermann, K., Wu, D., Stewart, A. J. & Bode, B. E., 28 Aug 2024, In: Dalton Transactions. 53, 32, p. 13529-13536 8 p.Research output: Contribution to journal › Article › peer-review
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Open access
Metallomic analysis of urine from individuals with and without Covid-19 infection reveals extensive alterations in metal homeostasis
da Silva Leal, K. N., da Silva, A. B. S., Fonseca, E. K. B., de Oliveira Moreira, O. B., de Lemos, L. M., de Oliviera, M. A. L., Stewart, A. J. & Arruda, M. A. Z., Dec 2024, In: Journal of Trace Elements in Medicine and Biology. 86, 11 p., 127557.Research output: Contribution to journal › Article › peer-review
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Open access
Optimizing the performance of single-cell ICP-MS for Fe and Zn determination in human umbilical vascular endothelial cells
Leal, K. N. S., da Silva, A. B. S., Aragão, A. Z. B., Ramos, C. H. I., Stewart, A. J. & Arruda, M. A. Z., 1 Jul 2024, In: Microchemical Journal. 202, 10 p., 110696.Research output: Contribution to journal › Article › peer-review
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Open access
Recent advances in metalloproteomics
Coverdale, J. P. C., Polepalli, S., Arruda, M. A. Z., Santos Da Silva, A. B., Stewart, A. J. & Blindauer, C. A., 13 Jan 2024, In: Biomolecules. 14, 1, 31 p., 104.Research output: Contribution to journal › Review article › peer-review
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Open access
Targeted removal of the FA2 site on human albumin prevents fatty acid-mediated inhibition of Zn2+-binding
Wu, D., Hierons, S. J., Polepalli, S., Gucwa, M., Fritzen, R., Markiewicz, M., Sabín, J., Minor, W., Murzyn, K., Blindauer, C. A. & Stewart, A. J., 1 Jun 2024, In: Journal of Lipid Research. 65, 6, 12 p., 100560.Research output: Contribution to journal › Article › peer-review
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Open access
Editorial: Insulin resistance and cardiovascular disease
Stewart, A. J., Tuncay, E., Pitt, S. J. & Rainbow, R. D., 4 Aug 2023, In: Frontiers in Endocrinology. 14, 3 p., 1266173.Research output: Contribution to journal › Editorial › peer-review