Research areas
My research is interdisciplinary and sits at the interface between the basic sciences and medicine. Research in my laboratory is focused upon how metal ions are handled in the body and the roles they play in regulating medically/physiologically relevant processes. Collectively, my work provides detailed and reliable data relating to the transport and speciation of metal ions (particularly zinc and calcium) in the circulation and new insights into their cellular functions and role in disease states. Currently my team are examining ways in which defective metal handling contributes to pathogenesis of cardiovascular diseases, including vascular eye disease and dementia.
PhD supervision
- Timothy Redpath
- Keira Hughes
- Quenton Hurst
- Claudia Harper
- Hasnain Ahmed
- Boyang Lin
- Mark Kelly
- Jordan Marsh
Selected publications
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Open access
Changes in fibrin clot properties in patients after Roux en-Y gastric bypass surgery
Abbas, K., Hierons, S. J., Pechlivani, N., Phoenix, F., Alexander, R., King, R., Ajjan, R. A. & Stewart, A. J., Feb 2024, In: Research and Practice in Thrombosis and Haemostasis. 8, 2, 8 p., e102361.Research output: Contribution to journal › Article › peer-review
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Open access
EPR spectroscopic characterisation of native CuII-binding sites in human serum albumin
Ackermann, K., Wu, D., Stewart, A. J. & Bode, B. E., 28 Aug 2024, In: Dalton Transactions. 53, 32, p. 13529-13536 8 p.Research output: Contribution to journal › Article › peer-review
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Open access
Metallomic analysis of urine from individuals with and without Covid-19 infection reveals extensive alterations in metal homeostasis
da Silva Leal, K. N., da Silva, A. B. S., Fonseca, E. K. B., de Oliveira Moreira, O. B., de Lemos, L. M., de Oliviera, M. A. L., Stewart, A. J. & Arruda, M. A. Z., Dec 2024, In: Journal of Trace Elements in Medicine and Biology. 86, 11 p., 127557.Research output: Contribution to journal › Article › peer-review
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Open access
Optimizing the performance of single-cell ICP-MS for Fe and Zn determination in human umbilical vascular endothelial cells
Leal, K. N. S., da Silva, A. B. S., Aragão, A. Z. B., Ramos, C. H. I., Stewart, A. J. & Arruda, M. A. Z., 1 Jul 2024, In: Microchemical Journal. 202, 10 p., 110696.Research output: Contribution to journal › Article › peer-review
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Open access
Recent advances in metalloproteomics
Coverdale, J. P. C., Polepalli, S., Arruda, M. A. Z., Santos Da Silva, A. B., Stewart, A. J. & Blindauer, C. A., 13 Jan 2024, In: Biomolecules. 14, 1, 31 p., 104.Research output: Contribution to journal › Review article › peer-review
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Open access
Targeted removal of the FA2 site on human albumin prevents fatty acid-mediated inhibition of Zn2+-binding
Wu, D., Hierons, S. J., Polepalli, S., Gucwa, M., Fritzen, R., Markiewicz, M., Sabín, J., Minor, W., Murzyn, K., Blindauer, C. A. & Stewart, A. J., 1 Jun 2024, In: Journal of Lipid Research. 65, 6, 12 p., 100560.Research output: Contribution to journal › Article › peer-review
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Open access
Editorial: Insulin resistance and cardiovascular disease
Stewart, A. J., Tuncay, E., Pitt, S. J. & Rainbow, R. D., 4 Aug 2023, In: Frontiers in Endocrinology. 14, 3 p., 1266173.Research output: Contribution to journal › Editorial › peer-review
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Open access
Five new diarylbutyrolactones and sesquilignans from Saussurea medusa and their inhibitory effects on LPS-induced NO production
Cao, J.-Y., Wang, Z.-Y., Stewart, A. J., Dong, Q., Zhao, Y., Mei, L.-J., Tao, Y.-D. & Yu, R.-T., 1 Jun 2023, In: Planta Medica. 89, 06, p. 663-673 11 p.Research output: Contribution to journal › Article › peer-review
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Open access
Investigating native metal ion binding sites in mammalian histidine-rich glycoprotein
Ackermann, K., Khazaipoul, S., Wort, J., Sobczak, A. I. S., El Mkami, H., Stewart, A. J. & Bode, B. E., 12 Apr 2023, In: Journal of the American Chemical Society. 145, 14, p. 8064-8072 9 p.Research output: Contribution to journal › Article › peer-review
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Open access
Magnesium deficiency and cardiometabolic disease
Fritzen, R., Davies, A., Veenhuizen, M., Campbell, M., Pitt, S. J., Ajjan, R. A. & Stewart, A. J., 17 May 2023, In: Nutrients. 15, 10, 19 p., 2355.Research output: Contribution to journal › Review article › peer-review