Prof Andy Lynch
Professor of Statistics in Bioscience
Biography
Professor Lynch joined the University of St Andrews in 2017 after 15 years at the University of Cambridge working in the Department of Public Health and Primary Care, The Department of Oncology and for the most part the Cancer Research UK Cambridge Institute. Divided between the Schools of Medicine, and Mathematics and Statistics, in St Andrews his research is divided between the development and application of analysis methods - typically in the context of cancer genomics.
Research areas
Professor Lynch works on the development and application of analysis methods for cancer sequencing data. This includes questions of experimental design within cancer genomics, fundamental questions regarding the extraction of data (and uncertainty) from modern biological methods, methods for answering biological and clinical questions in new ways, and applications to multiple cancer types (including Prostate, Glioblastoma, Oesophageal, Breast, Renal, Ovarian and Lung).
PhD supervision
- Katherine O'Neill
- Xiaoyue Yang
Selected publications
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Open access
Evidencing the intersection of environmental, socioeconomic, behavioural and demographic drivers of antibacterial resistance in East Africa
Keenan, K., Papathomas, M., Mshana, S. E., Asiimwe, B., Kiiru, J., Lynch, A. G., Kesby, M., Neema, S., Mwanga, J. R., Mushi, M. F., Green, D. L., Jing, W., Olamijuwon, E., Zhang, Q., Sippy, R., Fredricks, K. J., Gillespie, S. H., Sabiti, W., Bazira, J., Sloan, D. J., & 7 others , 15 Feb 2024, Rochester, NY: SSRN, 26 p.Research output: Working paper › Preprint
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Open access
Genomic evolution shapes prostate cancer disease type
CRUK-ICGC Prostate Group, Woodcock, D. J., Sahli, A., Teslo, R., Bhandari, V., Gruber, A. J., Ziubroniewicz, A., Gundem, G., Xu, Y., Butler, A., Anokian, E., Pope, B. J., Jung, C-H., Tarabichi, M., Dentro, S. C., Farmery, J. H. R., Van Loo, P., Warren, A. Y., Gnanapragasam, V., Hamdy, F. C., & 16 others , 13 Mar 2024, (E-pub ahead of print) In: Cell Genomics. 4, 13, 31 p., 100511.Research output: Contribution to journal › Article › peer-review
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Open access
Predominance of multidrug-resistant bacteria causing urinary tract infections among symptomatic patients in East Africa: a call for action
Maldonado-Barragán, A., Mshana, S. E., Keenan, K., Ke, X., Gillespie, S. H., Stelling, J., Maina, J., Bazira, J., Muhwezi, I., Mushi, M. F., Green, D. L., Kesby, M., Lynch, A. G., Sabiiti, W., Sloan, D. J., Sandeman, A., Kiiru, J., Asiimwe, B. & Holden, M. T. G., Feb 2024, In: JAC-Antimicrobial Resistance. 6, 1, 11 p., dlae019.Research output: Contribution to journal › Article › peer-review
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Open access
Ultra-sensitive detection of circulating tumour DNA enriches for patients with greater risk of recurrence in clinically localised prostate cancer
Pope, B., Park, G., Lau, E., Belic, J., Lach, R., George, A., McCoy, P., Nguyen, A., Grima, C., Campbell, B., Jung, C., Ditter, E-J., Zhao, H., Wedge, D., Brewer, D., Lynch, A., Dev, H., Gnanpragasam, V., Rosenfeld, N., Hovens, C., & 3 others , 1 Apr 2024, In: European Urology. 85, 4, p. 407-410 4 p.Research output: Contribution to journal › Letter › peer-review
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Open access
The role of multidimensional poverty in antibiotic misuse: a mixed-methods study of self-medication and non-adherence in Kenya, Tanzania, and Uganda
Green, D. L., Keenan, K., Fredricks, K. J., Huque, S. I., Mushi, M. F., Kansiime, C., Asiimwe, B., Kiiru, J., Mshana, S. E., Neema, S., Mwanga, J. R., Kesby, M., Lynch, A. G., Worthington, H., Olamijuwon, E., Abed Al Ahad, M., Aduda, A., Njeru, J. M., Mmbaga, B. T., Bazira, J., & 14 others , 1 Jan 2023, In: The Lancet Global Health. 11, 1, p. e59-e68 10 p.Research output: Contribution to journal › Article › peer-review
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Ultrasensitive Detection of Circulating Tumour DNA enriches for Patients with a Greater Risk of Recurrence of Clinically Localised Prostate Cancer
Pan Prostate Cancer Group (PPCG), 19 Feb 2024, In: European Urology. 85, 4, p. 407-410 4 p.Research output: Contribution to journal › Article › peer-review
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Open access
Unravelling patient pathways in the context of antibacterial resistance in East Africa
HATUA Consortium, Keenan, K., Fredricks, K. J., Al Ahad, M. A., Neema, S., Mwanga, J. R., Kesby, M., Mushi, M. F., Aduda, A., Green, D. L., Lynch, A. G., Huque, S. I., Mmbaga, B. T., Worthington, H., Kansiime, C., Olamijuwon, E., Ntinginya, N. E., Loza, O., Bazira, J., Maldonado-Barragán, A., & 15 others , 19 Jun 2023, In: BMC Infectious Diseases. 23, 1, 12 p., 414.Research output: Contribution to journal › Article › peer-review
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Open access
Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS
Guo, N., Minas, G., Synowsky, S. A., Dunne, M. R., Ahmed, H., McShane, R., Bhardwaj, A., Donlon, N. E., Lorton, C., O'Sullivan, J., Reynolds, J. V., Caie, P. D., Shirran, S. L., Lynch, A., Stewart, A. J. & Arya, S., 30 Aug 2022, In: Journal of Proteomics. 266, 11 p., 104684.Research output: Contribution to journal › Article › peer-review
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Open access
Low-cost and clinically applicable copy number profiling using repeat DNA
Abujudeh, S., Zeki, S., van Lanshot, M., Pusang, M., Weaver, J., li, X., Noorani, A., Metz, A., Bornschein, J., Bower, L., Miremedi, A., Fitzgerald, R., Morrissey, E. & Lynch, A., 17 Aug 2022, In: BMC Genomics. 23, 599.Research output: Contribution to journal › Article › peer-review
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Open access
Microbiomes of urine and the prostate are linked to human prostate cancer risk groups
Hurst, R., Meader, E., Gihawi, A., Rallapalli, G., Clark, J., Kay, G. L., Webb, M., Manley, K., Curley, H., Walker, H., Kumar, R., Schmidt, K., Crossman, L., Eeles, R. A., Wedge, D. C., Lynch, A. G., Massie, C. E., CRUK-ICGC Prostate Group, Yazbek-Hanna, M., Rochester, M., & 8 others , 1 Aug 2022, In: European Urology Oncology. 5, 4, p. 412-419 8 p.Research output: Contribution to journal › Article › peer-review