Dr Tanja van Mourik
Reader
Biography
Dr Tanja van Mourik is a computational chemist in the School of Chemistry. She joined St Andrews as a Royal Society Research Fellow in 2006. She was appointed Senior Lecturer in 2008 and Reader in 2014.
After obtaining her PhD in 1994 (Utrecht, the Netherlands), she spent three years as a Postdoctoral Research Associate (PDRA) at the Pacific Northwest National Laboratory in Richland (USA) and worked three years as a PDRA at University College London (UCL). She was awarded a Royal Society University Research Fellowship in Oct 2000, which she took up at UCL and relocated to St Andrews in April 2006. She was admitted as a Fellow of the Royal Society of Chemistry in 2013. She is currently Secretary of the EuChemS Division of Computational Chemistry. She is the Equality & Diversity Officer and Athena SWAN coordinator in the School of Chemistry, which holds a Silver Athena Bronze Award. Her research interests include the application of quantum chemical methods to study the properties of molecules, specifically those of biological interest. She has over 100 publications in the field.
Teaching
Dr Tanja van Mourik teaches physical and computational chemistry in the School of Chemistry. Current undergraduate courses include physical chemistry for direct-entry 2nd-year students (CH1402), 3rd-year computational chemistry (CH3721: lab course on molecular quantum chemistry and CH3616/CH3717: a lecture course on methods used in medicinal chemistry) and a fourth-year lab/lecture course on molecular quantum chemistry (CH4421). Postgraduate courses include a SUPA course on Computational Chemistry (SUPACCH) broadcast to all participating universities in Scotland and Programming in Fortran 95. Dr van Mourik is convener of a core 1st-year chemistry course on physical and inorganic chemistry (CH1402), several 3rd-year courses on physical chemistry (CH3716 and CH3717), and a 4th-year Scientific Writing course (CH4431).
Research areas
The area of computational quantum chemistry has developed drastically over the last decades, due to both increased computer power and the efficient implementation of quantum chemical methods in readily available computer programs. Because of this, accurate computational techniques can now be applied to much larger systems than before, bringing the area of biochemistry within the scope of electronic structure quantum chemistry (ab initio methods and density functional theory).
Research in the Van Mourik group focuses on studying molecules of biological interest using accurate quantum chemical methods. Current research areas include the conformation of flexible biomolecules, the calculation of spectroscopic (infrared and nuclear magnetic resonance) properties, solvation effects and intermolecular interactions with emphasis on sigma-hole interactions. Our research efforts also include the investigation of methodological accuracy, such as the determination of the intrinsic accuracy of methods, basis set convergence, and the elimination of methodological errors.
PhD supervision
- Rochelle Ferns Dsouza
- Lakshmi Priya M
- Peter Starrs
Selected publications
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Open access
The destabilization of hydrogen bonds in an external E-field for improved switch performance
Xu, T., Momen, R., Azizi, A., van Mourik, T., Früchtl, H., Kirk, S. R. & Jenkins, S., 13 Apr 2019, (E-pub ahead of print) In: Journal of Computational Chemistry. Early ViewResearch output: Contribution to journal › Article › peer-review
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Open access
Thermodynamics of 5-bromouracil tautomerisation from first-principles molecular dynamics simulations
Holroyd, L. F., Buehl, M., Gaigeot, M.-P. & van Mourik, T., 1 Jan 2019, Quantum Systems in Physics, Chemistry and Biology - Theory, Interpretation, and Results. Jenkins, S., Kirk, S., Maruani, J. & Brandas, E. (eds.). Academic Press/Elsevier , p. 109-128 (Advances of Quantum Chemistry; vol. 78).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Open access
Competition between hydrogen and halogen bonding in halogenated 1-methyluracil: water systems
Hogan, S. W. L. & van Mourik, T., 30 Mar 2016, In: Journal of Computational Chemistry. 37, 8, p. 763-770Research output: Contribution to journal › Article › peer-review
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Open access
Tyrosine-glycine revisited: resolving the discrepancy between theory and experiment
Holroyd, L. F. & van Mourik, T., 4 Feb 2015, In: Chemical Physics Letters. 621, p. 124-129Research output: Contribution to journal › Article › peer-review
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Open access
Uniting cheminformatics and chemical theory to predict the intrinsic aqueous solubility of crystalline druglike molecules
McDonagh, J., Nath, N., De Ferrari, L., van Mourik, T. & Mitchell, J. B. O., 24 Feb 2014, In: Journal of Chemical Information and Modeling. 54, 3, p. 844-856 13 p.Research output: Contribution to journal › Article › peer-review
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Open access
New class of metal bound molecular switches involving H-tautomerism
Simpson, G. J., Hogan, S. W. L., Caffio, M., Adams, C. J., Fruchtl, H. A., van Mourik, T. & Schaub, R., 12 Feb 2014, In: Nano Letters. 14, 2, p. 634-639Research output: Contribution to journal › Article › peer-review