Biography
John C. WALTON joined the faculty of Dundee University in 1967 and moved to St. Andrews University in 1970, rising to full professor in 1997 and becoming Research Professor in 2007. He has worked on the application of physical organic methods to organic mechanisms and is known for EPR spectroscopic studies of many kind of radicals. Recently he has been developing radical-mediated synthetic protocols including those based around: “pro-aromatic” cyclohexadienyl reagents, oxime derivatives, photoredox methods employing titanium dioxide and for research on radical enhancement of heterolysis. He has published over 300 articles in learned journals as well as 3 books. He was awarded the Royal Society of Chemistry silver medal for Organic Reaction Mechanisms in 1994 and was elected Fellow of the Royal Society of Edinburgh in 1995.
Research areas
My main interest is in free radicals and the development of organic syntheses and novel materials based on these species. Early work was concerned with the addition of free radicals to alkenes. Currently, my research centres in (i) the development of free radical synthetic methods based on derivatives of oximes (ii) photoredox methods with carboxylic acids (iii) boron-containing radicals (iv) the enhancement of acidity and promotion of heterolytic dissociation by radicals. These methods show promise for environmentally friendly organic preparations. Studies of radical structures and reactions by Electron Paramagnetic Resonance spectroscopy and computational methods are being successfully applied to aid in understanding radical mechanisms.
Selected publications
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Open access
5-endo cyclizations of NHC-boraallyl radicals bearing ester substituents: characterization of derived 1,2-oxaborole radicals and boralactones
Dai, W., McFadden, T. R., Curran, D. P., Früchtl, H. A. & Walton, J. C., 21 Nov 2018, In: Journal of the American Chemical Society. 140, 46, p. 15868-15875 8 p.Research output: Contribution to journal › Article › peer-review
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Open access
Enhanced proton loss from neutral free radicals: toward carbon-centered superacids
Walton, J. C., 8 Feb 2018, In: Journal of Physical Chemistry A. 122, 5, p. 1422-1431 10 p.Research output: Contribution to journal › Article › peer-review
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Open access
Generation and structure of unique boriranyl radicals
Walton, J. C., McFadden, T. R. & Curran, D. P., 22 Nov 2017, In: Journal of the American Chemical Society. 139, 46, p. 16514-16517Research output: Contribution to journal › Article › peer-review
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Open access
Radical-enhanced acidity: why bicarbonate, carboxyl, hydroperoxyl, and related radicals are so acidic
Walton, J. C., 12 Oct 2017, In: Journal of Physical Chemistry A. 121, 40, p. 7761-7767 7 p.Research output: Contribution to journal › Article › peer-review
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Open access
Bicarbonate and alkyl carbonate radicals: structural integrity and reactions with lipid components
Buehl, M., DaBell, P., Manley, D., McCaughan, R. & Walton, J. C., 30 Dec 2015, In: Journal of the American Chemical Society. 137, 51, p. 16153–16162 10 p.Research output: Contribution to journal › Article › peer-review
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Open access
The oxime portmanteau motif: released heteroradicals undergo incisive EPR interrogation and deliver diverse heterocycles
Walton, J. C., Mar 2014, In: Accounts of Chemical Research. 47, 4, p. 1406-1416Research output: Contribution to journal › Article › peer-review
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Open access
Dissociation or cyclization: options for a triad of radicals released from oxime carbamates
McBurney, R. T. & Walton, J. C., 13 May 2013, In: Journal of the American Chemical Society. 135, 19, p. 7349–7354 6 p.Research output: Contribution to journal › Article › peer-review
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Unconventional Titania photocatalysis: direct deployment of carboxylic acids in alkylations and annulations
Manley, D., McBurney, R. T., Miller, P., Howe, R. F., Rhydderch, S. & Walton, J. C., 22 Aug 2012, In: Journal of the American Chemical Society. 134, 33, p. 13580-13583 4 p.Research output: Contribution to journal › Article › peer-review
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EPR studies of the generation, structure, and reactivity of N-heterocyclic carbene borane radicals
Walton, J. C., Brahmi, M. M., Fensterbank, L., Lacote, E., Malacria, M., Chu, Q., Ueng, S.-H., Solovyev, A. & Curran, D. P., 24 Feb 2010, In: Journal of the American Chemical Society. 132, 7, p. 2350-2358 9 p.Research output: Contribution to journal › Article › peer-review