Prof Allan Watson
Professor of Homogeneous Catalysis
Biography
Allan completed his MSci (2004) and PhD (2008) at the University of Strathclyde in Glasgow. After a postdoctoral fellowship (Lindemann Trust) at Princeton (2010) and industrial postdoctoral position at GlaxoSmithKline (2011), Allan took up his first independent position at the University of Strathclyde as Lecturer (2011-2015) and Senior Lecturer (2015-2017). Allan moved to the University of St Andrews to take up the position of Reader in Homogeneous Catalysis in 2017.
Teaching
Allan contributes to teaching at both sub-honours and honours classes, through lecturing in CH3612 Synthetic Methodology (7 Lectures and 4 tutorials), CH3621 Organic Chemistry Lab (12 hours), and contributes to tutorials for CH1601 Organic Chemistry (8 hours) and CH2601 Organic Chemistry (8 hours).
Research areas
Our group works to solve problems in catalysis by using mechanism and with a focus on application. We work across the field of homogeneous catalysis from transition metals (Pd, Cu, Ni) to organocatalysis and focus on making C–C and C–X bonds. The bonds we target are typically related to chemotypes present in bioactive molecules. We have active projects in medicinal chemistry (enzyme inhibitors), chemical biology (bioconjugation), and agrochemistry (SAR on natural product templates).
PhD supervision
- David Groves
- Michaela Cerna
- Joanna Urbanczyk
- Thomas Richardson
- Marek Varga
- Maria Mazhuga
- Tim Hilton
- Hrithik Manojkumar
- Adam Dickey
- Yating Guo
- Mia Harris
Selected publications
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Open access
A flow platform for degradation-free CuAAC bioconjugation
Hatit, M. Z. C., Reichenbach, L. F., Tobin, J. M., Vilela, F., Burley, G. A. & Watson, A. J. B., 1 Oct 2018, In: Nature Communications. 9, 7 p., 4021.Research output: Contribution to journal › Article › peer-review
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Open access
Biocatalytic synthesis of chiral N-functionalized amino acids
Hyslop, J., Lovelock, S. L., Sutton, P., Brown, K. K., Watson, A. J. B. & Roiban, G.-D., 21 Sept 2018, (E-pub ahead of print) In: Angewandte Chemie International Edition. Early ViewResearch output: Contribution to journal › Article › peer-review
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Open access
Catalytic enantioselective synthesis of α-chiral azaheteroaryl ethylamines by asymmetric protonation
Xu, C., Muir, C., Leach, A., Kennedy, A. & Watson, A. J. B., 1 Aug 2018, (E-pub ahead of print) In: Angewandte Chemie International Edition. In pressResearch output: Contribution to journal › Article › peer-review
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Open access
Scalable total synthesis and comprehensive structure–activity relationship studies of the phytotoxin coronatine
Littleson, M. M., Baker, C. M., Dalençon, A. J., Frye, E. C., Jamieson, C., Kennedy, A. R., Ling, K. B., McLachlan, M. M., Montgomery, M. G., Russell, C. J. & Watson, A. J. B., 16 Mar 2018, In: Nature Communications. 9, 1105.Research output: Contribution to journal › Article › peer-review
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Open access
Contra-thermodynamic, photocatalytic E→Z isomerization of styrenyl boron species: vectors to facilitate exploration of two-dimensional chemical space
Molloy, J. J., Metternich, J. B., Daniliuc, C. G., Watson, A. J. B. & Gilmour, R., 12 Mar 2018, In: Angewandte Chemie International Edition. 57, 12, p. 3168-3172Research output: Contribution to journal › Article › peer-review
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Open access
Interrogating Pd(II) anion metathesis using a bifunctional chemical probe: a transmetalation switch
Molloy, J. J., Seath, C. P., West, M. J., McLaughlin, C., Fazakerley, N. J., Kennedy, A. R., Nelson, D. J. & Watson, A. J. B., 10 Jan 2018, In: Journal of the American Chemical Society. 140, 1, p. 126-130 5 p.Research output: Contribution to journal › Article › peer-review
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Open access
Spectroscopic studies of the Chan-Lam amination: a mechanism-inspired solution to boronic ester reactivity
Vantourout, J. C., Miras, H. N., Isidro-Llobet, A., Sproules, S. & Watson, A. J. B., 5 Apr 2017, In: Journal of the American Chemical Society. 139, 13, p. 4769-4779 11 p.Research output: Contribution to journal › Article › peer-review
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Open access
Determining the origin of rate-independent chemoselectivity in CuAAC reactions: an alkyne-specific shift in rate-determining step
Seath, C. P., Burley, G. A. & Watson, A. J. B., 13 Mar 2017, In: Angewandte Chemie International Edition. 56, 12, p. 3314-3318 5 p.Research output: Contribution to journal › Article › peer-review
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Open access
Chemoselective oxidation of aryl organoboron systems enabled by boronic acid-selective phase transfer
Molloy, J. J., Clohessy, T. A., Irving, C., Anderson, N. A., Lloyd-Jones, G. C. & Watson, A. J. B., 1 Feb 2017, In: Chemical Science. 8, 2, p. 1551-1559Research output: Contribution to journal › Article › peer-review
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Open access
Chemoselective Suzuki-Miyaura cross-coupling via kinetic transmetallation
Fyfe, J. W. B., Fazakerley, N. J. & Watson, A. J. B., 24 Jan 2017, In: Angewandte Chemie International Edition. 56, 5, p. 1249-1253Research output: Contribution to journal › Article › peer-review