Prof Terry K Smith
Director of Biomedical Sciences Research Complex
Professor
Research areas
1) Biosynthesis and uptake of phospholipids in protozoan parasites.
2) The enzymology of biosynthetic enzymes in parasites.
3) Lipidomics and focussed metabolomics of pathogens.
4) Carbohydrate synthesis and “simple” chemistry towards drugs for neglected disease.
5) Structure, function & biosynthesis of parasite glycoconjugates including GPI anchors.
PhD supervision
- Vytautas Kuodis
- Berta Fatas
- Ngoc Anh Thu Trinh
- Veronica Harris
- Peter Black
Selected publications
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Open access
Cryo-EM structure of the R388 plasmid conjugative pilus reveals a helical polymer characterized by an unusual pilin/phospholipid binary complex
Vadakkepat, A. K., Xue, S., Redzej, A., Smith, T. K., Ho, B. T. & Waksman, G., 5 Sept 2024, In: Structure. 32, 9, p. 1335-1347 19 p.Research output: Contribution to journal › Article › peer-review
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Open access
Discovery of Trypanosoma brucei inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides
S. Mantilla, B., White, J. S., Mosedale, W. R. T., Gomm, A., Nelson, A., Smith, T. K. & Wright, M. H., 19 Oct 2024, In: Communications Chemistry. 7, 9 p., 237.Research output: Contribution to journal › Article › peer-review
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Open access
Potential trypanocidal activity of glycerol analogues
Humann, R. & Smith, T. K., 12 Sept 2024, (E-pub ahead of print) In: ChemistryOpen. Early View, 14 p., e202400094.Research output: Contribution to journal › Article › peer-review
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Revisiting the dipeptidyl carboxypeptidase inhibitor captopril as a source of pan anti-trypanosomatid agents
Garsi, J. B., Hocine, S., Hensienne, R., Moitessier, M., Denton, H., Major, L. L., Smith, T. K. & Hanessian, S., 15 Sept 2024, In: Bioorganic and Medicinal Chemistry Letters. 110, 12 p., 129883.Research output: Contribution to journal › Article › peer-review
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Open access
Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1
Tulloch, L. B., Tinti, M., Wall, R. J., Weidt, S. K., Corpas-Lopez, V., Dey, G., Smith, T. K., Fairlamb, A. H., Barrett, M. P. & Wyllie, S., 11 Jul 2024, (E-pub ahead of print) In: PLoS Pathogens. 20, 7, 23 p., e1012382.Research output: Contribution to journal › Article › peer-review
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Open access
The role of ion dissolution in metal and metal oxide surface inactivation of SARS CoV-2
Hilton, J. V., Nanao, Y., Flokstra, M. G., Askari, M., Smith, T. K., Di Falco, A., King, P., Wahl, P. & Adamson, C. S., Feb 2024, In: Applied and Environmental Microbiology. 90, 2, 15 p., e01553-23.Research output: Contribution to journal › Article › peer-review
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Open access
A type VII-secreted lipase toxin with reverse domain arrangement
Garrett, S. R., Mietrach, N., Deme, J., Bitzer, A., Yang, Y., Ulhuq, F. R., Kretschmer, D., Heilbronner, S., Smith, T. K., Lea, S. M. & Palmer, T., 19 Dec 2023, In: Nature Communications. 14, 16 p., 8438.Research output: Contribution to journal › Article › peer-review
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Open access
Adipocyte lipolysis protects mice against Trypanosoma brucei infection
Machado, H., Hofer, P., Zechner, R., Smith, T. K. & Figueiredo, L. M., 12 Oct 2023, In: Nature Microbiology. 8, p. 2020-2032 27 p.Research output: Contribution to journal › Article › peer-review
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Open access
An eggshell-localised annexin plays a key role in the coordination of the life cycle of a plant-parasitic nematode with its host
Price, J. A., Ali, M. F., Major, L. L., Smith, T. K. & Jones, J. T., 13 Feb 2023, In: PLoS Pathogens. 19, 2, 19 p., e1011147.Research output: Contribution to journal › Article › peer-review
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Surface-Functionalized Metal-Organic Frameworks for Binding Coronavirus Proteins
Desai, AV., Vornholt, SM., Major, LL., Ettlinger, R., Jansen, C., Rainer, DN., de Rome, R., So, V., Wheatley, PS., Edward, AK., Elliott, CG., Pramanik, A., Karmakar, A., Armstrong, R., Janiak, C., Smith, TK. & Morris, RE., 14 Feb 2023, (E-pub ahead of print) In: ACS Applied Materials & Interfaces. 8 p.Research output: Contribution to journal › Article › peer-review