Prof Sonja Vernes

Professor

Email: scv1@st-andrews.ac.uk

Research areas

Sonja Vernes leads the Neurogenetics of Vocal Communication Research Group that studies the genetics of vocal communication in mammals, as a way to understand the evolution and biological basis of human speech and language.

My research program aims to understand the neuro-genetic mechanisms underlying the evolution and encoding of speech and language by studying key language-related traits such as vocal learning. My research uses diverse, interdisciplinary approaches including;

- clinical genetic analyses investigating the genetic causes of speech and language disorders in human cohorts

- omics approaches to discover novel genes involved in vocal learning in animal models including transcriptomics, network building and de novo genome sequencing (with the Bat1K genome sequencing consortium; www.bat1k.com)

- molecular-genetic studies to examine the function of known language-related and vocal learning-related genes (e.g. those identified in clinical genetic studies)

- neurogenetic approaches to uncover vocal learning relevant circuits in a mammalian brain and create links between genes, neurobiology and vocal learning behaviour

- behavioural paradigms to determine the extent of vocal learning abilities in bat species as a model for mammalian vocal learning

This research program is pioneering the use of bats as the first tractable mammalian model of vocal learning in which it is possible to explore the neuro-genetic underpinnings of this complex behavioural trait. This highly interdisciplinary approach aims to answer fundamental questions about how vocal learning evolved, how it is biologically encoded, and inform our understanding of human spoken language and language disorders.

PhD supervision

Sixue Li
Nikita Groot
Alexa Clarke

Selected publications

Open access

Morphological diversity in the brains of 12 Neotropical bat species
van Tussenbroek, I. A., Knörnschild, M., Nagy, M., ten Cate, C. J. & Vernes, S. C., 12 Feb 2024, In: Acta Chiropterologica. 25, 2, p. 323-338 16 p.
Research output: Contribution to journal › Article › peer-review
Open access

The genome sequence of Molossus alvarezi González-Ruiz, Ramírez-Pulido and Arroyo-Cabrales, 2011 (Chiroptera, Molossidae)
Simmons, N. B., Ingala, M. R., Pieri, M., O'Toole, B. P., Gray, J. L., Philge, P., Volkert, T. L., Zhang, N., Abueg, L., Brajuka, N., Jarvis, E. D., Formenti, G., McCaffrey, K., Mai, M., Teeling, E. C., Vernes, S. & Bat1K Consortium, 12 Sept 2024, In: Wellcome Open Research. 9, 522, 13 p.
Research output: Contribution to journal › Article › peer-review
DNA methylation networks underlying mammalian traits
Haghani, A., Li, C. Z., Robeck, T. R., Zhang, J., Lu, A. T., Ablaeva, J., Acosta-Rodríguez, V. A., Adams, D. M., Alagaili, A. N., Almunia, J., Aloysius, A., Amor, N. M. S., Ardehali, R., Arneson, A., Baker, C. S., Banks, G., Belov, K., Bennett, N. C., Black, P. & Blumstein, D. T. & 170 others, Bors, E. K., Breeze, C. E., Brooke, R. T., Brown, J. L., Carter, G., Caulton, A., Cavin, J. M., Chakrabarti, L., Chatzistamou, I., Chavez, A. S., Chen, H., Cheng, K., Chiavellini, P., Choi, O.-W., Clarke, S., Cook, J. A., Cooper, L. N., Cossette, M.-L., Day, J., DeYoung, J., Dirocco, S., Dold, C., Dunnum, J. L., Ehmke, E. E., Emmons, C. K., Emmrich, S., Erbay, E., Erlacher-Reid, C., Faulkes, C. G., Fei, Z., Ferguson, S. H., Finno, C. J., Flower, J. E., Gaillard, J.-M., Garde, E., Gerber, L., Gladyshev, V. N., Goya, R. G., Grant, M. J., Green, C. B., Hanson, M. B., Hart, D. W., Haulena, M., Herrick, K., Hogan, A. N., Hogg, C. J., Hore, T. A., Huang, T., Izpisua Belmonte, J. C., Jasinska, A. J., Jones, G., Jourdain, E., Kashpur, O., Katcher, H., Katsumata, E., Kaza, V., Kiaris, H., Kobor, M. S., Kordowitzki, P., Koski, W. R., Krützen, M., Kwon, S. B., Larison, B., Lee, S.-G., Lehmann, M., Lemaître, J.-F., Levine, A. J., Li, X., Li, C., Lim, A. R., Lin, D. T. S., Lindemann, D. M., Liphardt, S. W., Little, T. J., Macoretta, N., Maddox, D., Matkin, C. O., Mattison, J. A., McClure, M., Mergl, J., Meudt, J. J., Montano, G. A., Mozhui, K., Munshi-South, J., Murphy, W. J., Naderi, A., Nagy, M., Narayan, P., Nathanielsz, P. W., Nguyen, N. B., Niehrs, C., Nyamsuren, B., O'Brien, J. K., Ginn, P. O., Odom, D. T., Ophir, A. G., Osborn, S., Ostrander, E. A., Parsons, K. M., Paul, K. C., Pedersen, A. B., Pellegrini, M., Peters, K. J., Petersen, J. L., Pietersen, D. W., Pinho, G. M., Plassais, J., Poganik, J. R., Prado, N. A., Reddy, P., Rey, B., Ritz, B. R., Robbins, J., Rodriguez, M., Russell, J., Rydkina, E., Sailer, L. L., Salmon, A. B., Sanghavi, A., Schachtschneider, K. M., Schmitt, D., Schmitt, T., Schomacher, L., Schook, L. B., Sears, K. E., Seifert, A. W., Shafer, A. B. A., Shindyapina, A. V., Simmons, M., Singh, K., Sinha, I., Slone, J., Snell, R. G., Soltanmohammadi, E., Spangler, M. L., Spriggs, M., Staggs, L., Stedman, N., Steinman, K. J., Stewart, D. T., Sugrue, V. J., Szladovits, B., Takahashi, J. S., Takasugi, M., Teeling, E. C., Thompson, M. J., Van Bonn, B., Vernes, S. C., Villar, D., Vinters, H. V., Vu, H., Wallingford, M. C., Wang, N., Wilkinson, G. S., Williams, R. W., Yan, Q., Yao, M., Young, B. G., Zhang, B., Zhang, Z., Zhao, Y., Zhao, P., Zhou, W., Zoller, J. A., Ernst, J., Seluanov, A., Gorbunova, V., Yang, X. W., Raj, K. & Horvath, S., 11 Aug 2023, In: Science. 381, 6658, eabq5693.
Research output: Contribution to journal › Article › peer-review
Open access

The genome sequence of Rhynchonycteris naso, Peters, 1867 (Chiroptera, Emballonuridae, Rhynchonycteris)
Alvarez van Tussenbroek, I., Knörnschild, M., Nagy, M., O'Toole, B. P., Formenti, G., Philge, P., Zhang, N., Abueg, L., Brajuka, N., Jarvis, E. D., Volkert, T. L., Gray, J. L., Pieri, M., Mai, M., Teeling, E. C., Vernes, S. & Bat1K Consortium, 10 Jul 2024, In: Wellcome Open Research. 9, 361, 13 p.
Research output: Contribution to journal › Article › peer-review
Open access

Genotype-phenotype correlation in contactin-associated protein-like 2 (CNTNAP-2) developmental disorder
D'Onofrio, G., Accogli, A., Severino, M., Caliskan, H., Kokotović, T., Blazekovic, A., Jercic, K. G., Markovic, S., Zigman, T., Goran, K., Barišić, N., Duranovic, V., Ban, A., Borovecki, F., Ramadža, D. P., Barić, I., Fazeli, W., Herkenrath, P., Marini, C. & Vittorini, R. & 30 others, Gowda, V., Bouman, A., Rocca, C., Alkhawaja, I. A., Murtaza, B. N., Rehman, M. M. U., Al Alam, C., Nader, G., Mancardi, M. M., Giacomini, T., Srivastava, S., Alvi, J. R., Tomoum, H., Matricardi, S., Iacomino, M., Riva, A., Scala, M., Madia, F., Pistorio, A., Salpietro, V., Minetti, C., Rivière, J.-B., Srour, M., Efthymiou, S., Maroofian, R., Houlden, H., Vernes, S. C., Zara, F., Striano, P. & Nagy, V., 14 May 2023, In: Human Genetics. 17 p.
Research output: Contribution to journal › Article › peer-review
Open access

The genome sequence of Tadarida brasiliensis I. Geoffroy Saint-Hilaire, 1824 [Molossidae; Tadarida]
Webster, C. F., Smotherman, M., Pippel, M., Brown, T., Winkler, S., Pieri, M., Mai, M., Myers, E. W., Teeling, E. C., Vernes, S. & Bat1K Consortium, 29 Feb 2024, In: Wellcome Open Research. 9, 98, 16 p.
Research output: Contribution to journal › Article › peer-review
Open access

How genomics can help biodiversity conservation
European Reference Genome Atlas Consortium, Theissinger, K., Fernandes, C., Formenti, G., Bista, I., Berg, P. R., Bleidorn, C., Bombarely, A., Crottini, A., Gallo, G. R., Godoy, J. A., Jentoft, S., Malukiewicz, J., Mouton, A., Oomen, R. A., Paez, S., Palsbøll, P. J., Pampoulie, C., Ruiz-López, M. J. & Secomandi, S. & 12 others, Svardal, H., Theofanopoulou, C., de Vries, J., Waldvogel, A.-M., Zhang, G., Jarvis, E. D., Bálint, M., Ciofi, C., Waterhouse, R. M., Mazzoni, C. J., Höglund, J. & Vernes, S., Jul 2023, In: Trends in Genetics. 39, 7, p. 545-559 15 p.
Research output: Contribution to journal › Review article › peer-review
Open access

The genome sequence of Daubenton's bat, Myotis daubentonii (Kuhl, 1817)
Ruedi, M., Vernes, S., Teeling, E. C., Mai, M., Blaxter, M., Wellcome Sanger Institute Tree of Life & Darwin Tree of Life Consortium, 1 Mar 2024, In: Wellcome Open Research. 9, 107, 13 p.
Research output: Contribution to journal › Article › peer-review
Open access

The genome sequence of Molossus nigricans (Chiroptera, Molossidae; Miller, 1902)
Simmons, N. B., Ingala, M. R., Pieri, M., Volkert, T. L., Singh, L. N., Philip, P., Lindsey, L. L., Zhang, N., Gray, J. L., O'Toole, B. P., Mai, M., Teeling, E. C., Vernes, S. C., Bat Biology Foundation & Bat1K Consortium, 5 May 2023, In: Wellcome Open Research. 8, 13 p., 198.
Research output: Contribution to journal › Article › peer-review
Open access

The genome sequence of the Brown Long-eared bat, Plecotus auritus (Linnaeus 1758)
Millar, A., Vernes, S., Teeling, E. C., Mai, M., Blaxter, M., Darwin Tree of Life Consortium & Wellcome Sanger Institute Tree of Life, 9 May 2024, In: Wellcome Open Research. 9, 246, 15 p.
Research output: Contribution to journal › Article › peer-review

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