Dr Magnus Alphey

X-ray Facility Manager

Researcher profile

Phone

+44 (0)1334 46 7257

Email

msa31@st-andrews.ac.uk

 

Selected publications

• Open access

  Crystal structure, steady-state and pre-steady-state kinetics of Acinetobacter baumannii ATP phosphoribosyltransferase

  Read, B., Cadzow, A., Alphey, M. S., Mitchell, J. B. O. & da Silva, R. G., 16 Jan 2024, In: Biochemistry. 63, 2, p. 230-240 11 p.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Canonical binding of Chaetomium thermophilum DNA polymerase δ/ζ subunit PolD3 and flap endonuclease Fen1 to PCNA

  Alphey, M. S., Wolford, C. & MacNeill, S., 18 Dec 2023, In: Frontiers in Molecular Biosciences. 10, 9 p., 1320648.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation

  Fisher, G., Corbella, M., Alphey, M. S., Nicholson, J., Read, B., Kamerlin, S. C. L. & da Silva, R. G., 9 Dec 2022, In: Nature Communications. 13, 15 p., 7607.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Non‐canonical binding of the Chaetomium thermophilum PolD4 N‐terminal PIP motif to PCNA involves Q‐pocket and compact 2‐fork plug interactions but no 3₁₀ helix

  Yang, D., Alphey, M. S. & MacNeill, S., 22 Aug 2022, (E-pub ahead of print) In: FEBS Journal. Early View, 14 p., 16590.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Next generation glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: an extended SAR study to direct future design

  Xiao, G., Alphey, M. S., Tran, F., Pirrie, L., Milbeo, P., Zhou, Y., Bickel, J. K., Kempf, O., Kempf, K., Naismith, J. H. & Westwood, N. J., 15 Nov 2021, In: Bioorganic & Medicinal Chemistry. 50, 116477.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Mapping the structural path for allosteric inhibition of a short-form ATP phosphoribosyltransferase by histidine

  Thomson, C. M., Alphey, M. S., Fisher, G. & da Silva, R. G., 16 Jul 2019, In: Biochemistry. 58, 28, p. 3078-3086

  Research output: Contribution to journal › Article › peer-review

• Open access

  Catalytic and anticatalytic snapshots of a short-form ATP phosphoribosyltransferase

  Alphey, M. S., Fisher, G., Ge, Y., Gould, E. R., Guerreiro Machado, T. F., Liu, H., Florence, G. J., Naismith, J. H. & da Silva, R. G., 1 Jun 2018, In: ACS Catalysis. 8, 6, p. 5601-5610 10 p.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Kinetics and structure of a cold-adapted hetero-octameric ATP phosphoribosyltransferase

  Stroek, R., Ge, Y., Talbot, P. D., Glok, M. K., Bernas, K. E., Thomson, C. M., Gould, E. R., Alphey, M. S., Liu, H., Florence, G. J., Naismith, J. H. & da Silva, R. G., 7 Feb 2017, In: Biochemistry. 56, 5, p. 793-803 11 p.

  Research output: Contribution to journal › Article › peer-review

• Allosteric Competitive Inhibitors of the Glucose-1-phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa

  Alphey, M. S., Pirrie, L., Torrie, L. S., Abdelli Boulkeroua, W., Gardiner, M., Sarkar, A., Maringer, M., Oehlmann, W., Brenk, R., Scherman, M. S., McNeil, M., Rejzek, M., Field, R. A., Singh, M., Gray, D., Westwood, N. J. & Naismith, J., Feb 2013, In: ACS Chemical Biology. 8, 2, p. 387-396 10 p.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Structural insights into the mechanism and inhibition of the beta-Hydroxydecanoyl-Acyl carrier protein dehydratase from pseudomonas aeruginosa

  Moynie, L., Leckie, S. M., McMahon, S. A., Duthie, F. G., Koehnke, A., Taylor, J. W., Alphey, M. S., Brenk, R., Smith, A. D. & Naismith, J. H., 23 Jan 2013, In: Journal of Molecular Biology. 425, 2, p. 365-377 13 p.

  Research output: Contribution to journal › Article › peer-review

 

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