Prof Frank J Gunn-Moore

Co Director of the MacKenzie Institute (Science)

Professor

Researcher profile

Phone

+44 (0)1334 46 3525

Email

fjg1@st-andrews.ac.uk

 

Research areas

The prognosis for most neurodegenerative diseases is poor. The causes of the major diseases (eg: Alzheimer's, Parkinson's and Multiple Sclerosis) are complex, including genetic and environmental factors. All conspire to interfere with signalling pathways in neurons and glia which sustain growth and viability. My work focuses on factors that are involved in the promotion of correct neuronal function, and to do this we use a wide range of approaches that encompass biology, chemistry and physics. 

PhD supervision

• Stella Wigglesworth - Littlewood
• Pietro Esposito

Selected publications

• Open access

  Quantifying DNA damage following light sheet and confocal imaging of the mammalian embryo

  Chow, D. J. X., Schartner, E. P., Corsetti, S., Upadhya, A., Morizet, J., Gunn-Moore, F. J., Dunning, K. R. & Dholakia, K., 5 Sept 2024, (E-pub ahead of print) In: Scientific Reports. 14, 12 p., 20760.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Alzheimer’s disease-like neuropathology in three species of oceanic dolphin

  Vacher, M. C., Durrant, C. S., Rose, J., Hall, A. J., Spires-Jones, T. L., Gunn-Moore, F. & Dagleish, M. P., 1 Apr 2023, In: European Journal of Neuroscience. 57, 7, p. 1161-1179 19 p.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Development of submicromolar 17β-HSD10 inhibitors and their in vitro and in vivo evaluation

  Benek, O., Vaskova, M., Miskerikova, M., Schmidt, M., Andrys, R., Rotterova, A., Skarka, A., Hatlapatkova, J., Karasova, J. Z., Medvecky, M., Hroch, L., Vinklarova, L., Fisar, Z., Hroudova, J., Handl, J., Capek, J., Rousar, T., Kobrlova, T., Dolezal, R. & Soukup, O. & 3 others, Aitken, L., Gunn-Moore, F. & Musilek, K., 5 Oct 2023, In: European Journal Of Medicinal Chemistry. 258, 18 p., 115593.

  Research output: Contribution to journal › Article › peer-review

• Microlensed Fiber-based Poration

  Dholakia, K. (Inventor), Ma, N. (Inventor), Ashok, P. C. (Inventor), Stevenson, D. J. (Inventor) & Gunn-Moore, F. J. (Inventor), 3 Jan 2023, Patent No. 2801671

  Research output: Patent

• Open access

  The mitochondrial enzyme 17βHSD10 modulates ischemic and amyloid-β-induced stress in primary mouse astrocytes

  Metodieva, V., Smith, T. K. & Gunn-Moore, F. J., 12 Sept 2022, In: eNeuro. 9, 5, 24 p.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Willin/FRMD6 mediates mitochondrial dysfunction relevant to neuronal Aβ toxicity

  Chen, D., Yu, W., Aitken, L. & Gunn-Moore, F. J., 6 Oct 2022, In: Cells. 11, 19, 27 p., 3140.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Author Correction: Nanostructural Diversity of Synapses in the Mammalian Spinal Cord (Scientific Reports, (2020), 10, 1, (8189), 10.1038/s41598-020-64874-9)

  Broadhead, M. J., Bonthron, C., Arcinas, L., Bez, S., Zhu, F., Goff, F., Nylk, J., Dholakia, K., Gunn-Moore, F., Grant, S. G. N. & Miles, G. B., Dec 2021, In: Scientific Reports. 11, 1, 23160.

  Research output: Contribution to journal › Comment/debate › peer-review

• Open access

  Willin/FRMD6: a multi-functional neuronal protein associated with Alzheimer’s disease

  Chen, D., Yu, W., Aitken, L. & Gunn-Moore, F. J., 4 Nov 2021, In: Cells. 10, 11, 27 p., 3024.

  Research output: Contribution to journal › Review article › peer-review

• Open access

  Benzothiazolyl ureas are low micromolar and uncompetitive inhibitors of 17β-HSD10 with implications to Alzheimer’s disease treatment

  Schmidt, M., Benek, O., Vinklarova, L., Hrabinova, M., Zemanova, L., Chribek, M., Kralova, V., Hroch, L., Dolezal, R., Lycka, A., Prchal, L., Jun, D., Aitken, L., Gunn-Moore, F., Kuca, K. & Musilek, K., 17 Mar 2020, In: International Journal of Molecular Sciences. 21, 6, 26 p., 2059.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Brain region–specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer’s disease

  Dey, M., Gunn-Moore, F. J., Platt, B. & Smith, T. K., 31 Aug 2020, In: Lipids in Health and Disease. 19, 17 p., 201.

  Research output: Contribution to journal › Article › peer-review

 

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